Description
Melanoma inhibitory activity (MIA), also known as cartilage derived retinoic acid sensitive protein (CD-RAP)1, is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin. MIA is over-expressed in pancreatic cancer and has the potential of promoting the invasiveness of pancreatic cancer cells.2